Original Question: Can wellbutrin be used as an anecdote for SSRI related sexual dysfunction?
PICO Format:In patients with SSRI related sexual dysfunction, is bupropion/wellbutrin a beneficial adjunct to treat the sexual dysfunction in patients not desiring change of SSRI?
Searched Terms:buproprion, SSRI, sexual dysfunction
Where searched:pubmed
Answer:Adjunctive treatment with bupropion sustained release during a 12-week period significantly improved key aspects of sexual function in women with SSRI-induced sexual dysfunction.
At the end of the trial, the mean scores for desire, arousal, lubrication, and satisfaction were significantly higher in the bupropion group than the placebo group.
compared with baseline, desire increased by 86.4% (95%CI, p=0.001) and lubrication 69.2% (95% CI, p=0.001)
level of evidence: 1 (randomized controlled trial)
SOR B- B (inconsistent, patient oriented evidence)
Pub Med- Journal of Psychopharmacology
Safarinejad. “Reversal of SSRI-induced female sexual dysfunction by adjunctive bupropion in menstruating women: a double-blind, placebo-controlled and randomized study.” Journal of Psychopharmacology. 2011 Mar; 25(3): 370-8.
SORT :B Inconsistent or limited-quality patient-oriented evidence*
Completed by:Jen White, PGY-1
Date last updated:5/12/2011
